Hypolipidemic effect of aqueous and ethanol extracts of Alafia barteri (leaf and root) in formaldehyde-induced arthritis in male mice

Alafia barteri is valued for its effectiveness in the traditional medicine system in Nigeria and other African countries. This study aims at evaluating the hypolipidemic effect of the aqueous and ethanol leaf and root extracts of Alafia barteri in formaldehyde-induced arthritic mice. 77 healthy Swiss albino male mice (30-35 g) were randomized into eleven groups of five mice each and extracts were administered for 10 days at 200 mg/kg and 400 mg/kg. Arthritis was induced by sub-plantar injection of 0.1 mL of 2 % formaldehyde. Serum lipid profile was evaluated after blood sample collection. Results of this study revealed that the aqueous and ethanol leaf extracts caused significant reduction(p˂0.05) in triglyceride and total cholesterol levels, but increased HDL-cholesterol levels compared to the arthritic control which is suggestive of their hypo-lipidemic effects in arthritic mice.